Description
Composition Pertuzumab 420mg
Substitutes Pertuzumab 420mg
Shipping class Cold chain shipment
Medicine Overview of Perjeta 420mg 1s Injection
Uses of Perjeta 420mg 1s Injection
PERJETA is indicated for use in combination with trastuzumab and docetaxel for the treatment of patients with HER2-positive metastatic breast cancer who have not received prior anti-HER2 therapy or chemotherapy for metastatic disease.
Perjeta 420mg 1s Injection side effects
Common
Left Ventricular Dysfunction, Embryo-Fetal Toxicity, Infusion-Related Reactions, Hypersensitivity Reactions/Anaphylaxis.
How to use Perjeta 420mg 1s Injection
Perjeta will be given to you by a doctor or nurse in a hospital or clinic. It is given by a drip into a vein (intravenous infusion) once every three weeks. The amount of medicine you are given and how long the infusion will last are different for the first dose and following doses. The number of infusions you will be given depends on how you respond to treatment and whether you are receiving treatment before or after surgery (neoadjuvant or adjuvant therapy) or for disease which has spread. Perjeta is given with other cancer treatments (trastuzumab and chemotherapy).
How Perjeta 420mg 1s Injection works
Perjeta is a type of medicine called a “monoclonal antibody” which attaches itself to specific targets in your body and on the cancer cells. Perjeta recognises and attaches to a target called “human epidermal growth factor receptor 2” (HER2). HER2 is found in large amounts on the surface of some cancer cells where it stimulates their growth. When Perjeta attaches to the HER2 cancer cells, it may slow or stop the cancer cells from growing, or may kill them.
In Depth Information on Perjeta 420mg 1s Injection
Expert advice for Perjeta 420mg 1s Injection
- If you have ever had heart problems (such as heart failure, treatment for serious irregular heartbeats, uncontrolled high blood pressure, recent heart attack), your heart function will be checked before and during treatment with Perjeta and your doctor will run tests to check if your heart is working properly.
- If you have ever had heart problems during previous treatment with trastuzumab.
- If you have ever had a chemotherapy medicine from the class called anthracyclines, e.g. doxorubicin or epirubicin – these medicines can damage heart muscle and increase the risk of heart problems with Perjeta.
- Infusion reactions, allergic or anaphylactic (more severe allergic) reactions can happen. Your doctor or nurse will check for side effects during your infusion and for 30 to 60 minutes afterwards. If you get any serious reaction, your doctor may stop treatment with Perjeta.
- When Perjeta is given with other cancer treatments (trastuzumab and chemotherapy), the number of white blood cells may drop and fever (raised temperature) may develop. If you have inflammation of the digestive tract (e.g.sore mouth or diarrhoea) you may be more likely to develop this side effect.
- Treatment with Perjeta may cause severe diarrhoea. Diarrhoea is a condition where your body produces more watery stools than normal. If you experience severe diarrhoea while receiving your anti-cancer treatment, your doctor may start you on anti-diarrhoeal treatment and may stop your treatment with Perjeta until the diarrhoea is under control.
Perjeta 420mg 1s Injection related warnings
Special precautions for Perjeta 420mg 1s Injection
Alcohol
There is no significant data.
Pregnancy
Before starting treatment, you must tell your doctor or nurse if you are pregnant. They will advise you about the benefits and risks for you and your baby of taking Perjeta while you are pregnant. Tell your doctor straight away, if you get pregnant during treatment with Perjeta or during the 6 months after stopping treatment. Perjeta may harm the unborn baby. You should use effective contraception during treatment with Perjeta and for 6 months after stopping treatment.
Lactation
Before starting treatment, you must tell your doctor or nurse if you are breast-feeding.
Driving
Perjeta is unlikely to affect you being able to drive or use machines. However, if you get any infusion reactions, allergic or anaphylactic reactions, wait until these have gone away before driving or using machines.
Kidney
No clinical studies have been conducted to evaluate the effect of renal impairment on the pharmacokinetics of pertuzumab.
Liver
No clinical studies have been conducted to evaluate the effect of hepatic impairment on the pharmacokinetics of pertuzumab.
What if you miss a dose of Perjeta 420mg 1s Injection?
If you forget or miss your appointment to receive Perjeta make another appointment as soon as possible. If it has been 6 weeks or more since your last visit a higher Perjeta dose of 840 mg will be given to you.
